ANTIGEN PROTEIN OF MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS, GENE ENCODING THE SAME PROTEIN AND METHOD FOR DIAGNOSING MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS BY USING THE SAME PROTEIN

摘要

PROBLEM TO BE SOLVED: To provide an antigen protein of Mycobacterium avium subsp. paratuberculosis having IFN-γ-inducing ability and further clarify genetic information concerning the antigen protein of Mycobacterium avium subsp. paratuberculosis and readily enable mass production of the antigen protein of Mycobacterium avium subsp. paratuberculosis and to provide a method for accurately diagnosing Mycobacterium avium subsp. paratuberculosis in high sensitivity by using the antigen protein of Mycobacterium avium subsp. paratuberculosis having the IFN-γ-inducing ability.;SOLUTION: The present invention relates an antigen protein of Mycobacterium avium subsp. paratuberculosis composed of a specific amino acid sequence, a gene encoding the antigen protein of Mycobacterium avium subsp. paratuberculosis composed of a specific amino acid sequence, a cell in which the gene is induced so as to enable expression and a method for diagnosing Johne's disease comprising adding the protein or the cell to the cell of an animal to be examined, culturing the cell and detecting an interferon γ concentration in a culture supernatant.;COPYRIGHT: (C)2005,JPO&NCIPI