首页>
外国专利>
Methods for promoting polyamide uptake and nuclear accumulation in eukaryotic cells
Methods for promoting polyamide uptake and nuclear accumulation in eukaryotic cells
展开▼
机译:在真核细胞中促进聚酰胺吸收和核积累的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
A method for enhancing cellular uptake and redistributing gene regulating polyamides from the extranuclear areas in eukaryotic cells to the nucleus thereof. The method consists of administering to the eukaryotic cells a molecular trafficking compound. The administered molecular trafficking compound affects cellular pathways and mechanisms that accumulate polyamides in cytoplasmic vessicles and/or efflux polyamides from the intracellular regions of cell. The method also includes modifying polyamides to contain negatively-charged or acidic moieties wherein the moieties inhibit the accumulation of polyamides in cellular lysosomes. By affecting the cellular pathways and mechanisms, the polyamides are redistributed throughout the cell, whereby nuclear accumulation of the polyamides is enhanced.
展开▼