Lasofoxifene Racemic Purified and D - lasofoxifene Tartrate Purified and a method for the effective purification of Racemic lasofoxifene

摘要

Claim 1: a method to Purify cis - 4 - phenyl - [4 - (2 - 5 - 1 - iletoxi pyrrolidin-3-yl) phenyl] - minutebug - tetrahidronaftalen racemic - 2-ol, characterized in that it comprises: (a) in suspension cis - 5 6 - phenyl - [4 - (2) - pyrrolidin-3-yl - 1 - iletoxi) phenyl] - 5,6,7,Tetrahidronaftalen - 8 - 2 - ol in a racemic mixture of Ethanol and tetrahydrofuran to form a suspension; (b) heating the suspension Shake and cool; (c) the suspension of the step (b); and (d) collect a CIS - 4 - phenyl - [4 - (2 - 5 - 1 - iletoxi pyrrolidin-3-yl) - tetrahidronaftalen 5,6,7,8] - phenyl - 2 - ol Racemic Purified Solid.