Use of a benzodiazepine derivative or a pharmaceutically acceptable salt thereof, inhaler or nebulizer, product, uses of a product and a compound or pharmaceutically acceptable salt thereof, benzodiazepine derivative, compound, and pharmaceutical composition

摘要

"USE OF A BENZODIAZEPIN DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT OF THIS INHALER OR NEBULIZER, PRODUCT, USES OF A PRODUCT AND A PHARMACEUTICALLY ACCEPTABLE SALT OR COMPOUND, COMPOSITE, COMPOSITION, COMPOSITION, AND COMPOSITION. Benzodiazepine derivative of formula (I) and its pharmaceutically acceptable salts, are observed to be active against RSV. Formula (I) wherein: -R 13 represents C 1-6 alkyl; aryl or heteroaryl; R 2 represents hydrogen or C 1-6 alkyl; each R 3 is the same or different and represents halogen, hydroxy, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 alkylthio C 1-6 haloalkyl, C 1-6 haloalkoxy ~ 1-6 ~, amino, mono (C 1-6 alkyl) amino, di (C 1-6 alkyl) amino, nitro, Cyano, -CO ~ 2 ~ R 39, -CONR 39 R 39 39, -NH-CO-R 39, -S (O) R 39, -S (0) ~ 2 ~ R 39, -NH-S (0) ~ 2 ~ R 39, -S (O) NR 39 R 39 39 or -S (O) ~ 2 ~ NR 39 R 39 39 where each of R 39 and R 39 39 is the same or different and represents hydrogen or C1-6 alkyl; n is 0 to 3, R 4 is hydrogen or C 1-6 alkyl; R 6 is C 1-6 alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl (C 1-6 alkyl), heteroaryl (C 1-6 alkyl), carbocyclyl ( C 1-6 alkyl), heterocyclyl (C 1-6 alkyl), aryl-C (O) -C (O) -, heteroaryl-C (O) -C (O) -, carbocyclyl-C ( O) -C (O) -, heterocyclyl-C (O) -C (O) - or -XR6-6; - X represents -CO, -S (O) -OR -S (O) -2- and -R6-6 represents C1-6 alkyl, hydroxy, C1-6 alkoxy, C1-6 alkylthio 1-6, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl (C 1-6 alkyl), heteroaryl (C 1-6 alkyl), carbocyclyl (C 1-6 alkyl) -, heterocyclyl ( C 1-6 alkyl), aryl (C 1-6 hydroxyalkyl), heteroaryl (C 1-6 hydroxyalkyl), carbocyclyl (C 1-6 hydroxyalkyl) heterocyclyl (C 1-6 hydroxyalkyl) -, aryl (C 1-6 alkyl) -O-, heteroaryl (C 1-6 alkyl) -0-, carbocyclyl (C 1-6 alkyl) ~) -O, heterocyclyl- (C 1-6 alkyl) -O- or -NR 39 R 39 39 wherein each of R 39 and R 39 39 is the same or different and represents hydrogen, C 1-6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aryl (C 1-6 alkyl) -, heteroaryl (C 1-6 alkyl) -, carbocyclyl- (C 1-6 alkyl) - or heterocyclyl (C 1-6 alkyl) -.