Compound, pharmaceutical formulation, use of a compound, methods for prevention and / or treatment of conditions associated with glycogen synthase kinase-3 and disease prevention and / or treatment, and use of intermediates

摘要

"COMPOUND, PHARMACEUTICAL FORMULATION, USE OF A COMPOUND, METHODS FOR PREVENTION AND / OR TREATMENT OF CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTASE KINASE-3 AND FOR PREVENTION AND / OR TREATMENT OF DISEASES, AND, USE OF INTERMEDIES." The present invention relates to novel compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR¬ 5¬; phenyl foot or a 5- or 6-membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5- or 6-membered aromatic heterocyclic ring containing one or more nitrogen atoms; R is C 1-6 alkyl NR 10 10 R 11 or C 1-6 alkylazetidine; R¬ 10¬ is hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 0-6 alkyl C 3-6 cycloalkyl, C 0 alkylaryl -6-, C 0-61 alkyl heteroaryl or C 1-6 alkyl NR 8 8 R 9; R 11a is C 1-6 alkyl NR 8 8 R 9, C 0-6 alkyl C 3-6 cycloalkyl or C 0-6 alkylheterocycloalkyl; as a free base or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof, a process for its preparation and novel intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and the use of said active compounds in therapy.