Compound, pharmaceutical formulation, use of a compound, methods for prevention and / or treatment of conditions associated with glycogen synthase kinase-3 and disease prevention and / or treatment, process for preparing a compound, and use of intermediates

摘要

"COMPOUND, PHARMACEUTICAL FORMULATION, USE OF A COMPOUND, METHODS FOR PREVENTION AND / OR TREATMENT OF CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTASE KINASE-3 AND DISEASE PREVENTION AND / OR TREATMENT, PROCESS FOR AND PREPARATION OF THE PREPARATION, " The present invention relates to novel compounds of Formula (I) wherein Z is N; Y is CONR¬ 5¬, NR¬ 5¬CO, SO ~ 2 ~ NR¬ 5¬, NR¬ 5¬SO ~ 2 ~, CH ~ 2 ~ NR¬ 5¬, NR¬ 5¬, NR¬ 5¬CONR ¬ 5¬, CH ~ 2 ~ CO, CO, O or CH ~ 2 ~ O; X is CH or N; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S and said phenyl ring or 5 or 6 membered heteroaromatic ring may optionally be fused to a 5 to 6 membered ring, saturated, partially saturated or unsaturated, containing one or more atoms selected from C, N, O or S; Q is C-1-6-alkyl, C-2-6-alkenyl, a process for its preparation and novel intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and the use of said active compounds in therapy, such as how to provide compounds having an inhibitory effect on GSK3.