SPIRIT COMPOUNDS

摘要

The compounds of formula (I) (where A is an optionally substituted straight chain hydrocarbon having from 1 to 6 carbon atoms, optionally interrupted by an oxygen or nitrogen atom; Ar is aryl or heteroaryl, each of which is optionally substituted; n is 0 or 1; R is hydrogen or lower alkylene attached to an arbitrary, capable of binding position of A; T, U, V and W represent, independently, a nitrogen atom or an optionally substituted methin and at least two of T, U, V and W represent said methine group; X presents - N (SOR) -, -N (COR) - or -CO-; Y represents -C (R) (R) -, -O- or -N (R) -; Z represents methine or nitrogen atom), are antagonistic action against NPY and are useful as agents for treating various types of NPY related disorders, such as cardiovascular diseases, such as hypertension, nephropathy, heart disease, vascular spasms, arteriosclerosis, etc., central nervous system diseases, such like bulimia, depression, anxiety, seizures, epilepsy, dementia, pain, alcoholism, drug abuse, disorder strains caused by circadian rhythm disorders, schizophrenia, etc., metabolic disorders such as obesity, various types of diabetes, hormonal disorders, hypercholesterolemia, hyperlipidemia, etc., sexual and reproductive dysfunctions, and disorders of the motility of the gastrointestinal tract. International The application was published with the international search report.