3-INDOLINE DERIVATIVES USEFUL IN THE TREATMENT OF PSYCHIATRIC AND NEUROLOGIC DISORDERS

摘要

The present invention relates to novel 3-indoline derivatives of dopamine D4 receptors. The compounds according to the invention can be used to treat certain psychiatric and neurological disorders, especially various psychoses. The compounds of the invention also exhibit affinity for the 5-HT 2A receptors. In the compounds of the present invention, R1 is acyl, thioacyl or trifluoromethylsulfonyl or R12SO2-, R12OCO or R12SCO-, wherein R12 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or aryl, or R13R14NCO. or R13R14NCS-, and in the latter two, R13 and R14 are independently hydrogen or alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl or aryl, or R13 and R14 together form a pyrrolidinyl, piperidinyl or perhydroazepinyl group with the nitrogen atom to which they are attached. They are attached; n is an integer from 1 to 6; X is a vagymetine group of a carbon or nitrogen atom, and the dotted line starting from X is a bond when X is a carbon atom or a bond, when X is a nitrogen atom or a methine group; R ', R 1 and R 2 are independently hydrogen or alkyl optionally substituted by halogen; and R3-R11 are independently hydrogen or halogen or cyano, nitro, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, amino, alkylamino, dialkylamino, alkylcarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl , alkoxy, alkylthio, alkylsulfonyl, hydroxy, trifluoromethyl or trifluoromethylsulfonyl.