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APTAMERS CONTAINING SEQUENCES OF NUCLEIC ACIDS OR NUCLEIC ACID ANALOGUES BOUND HOMOLOGOUSLY, OR IN NOVEL COMPLEXES.
APTAMERS CONTAINING SEQUENCES OF NUCLEIC ACIDS OR NUCLEIC ACID ANALOGUES BOUND HOMOLOGOUSLY, OR IN NOVEL COMPLEXES.
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机译:包含核酸或核酸类似物序列均一地或以新的复合体形式结合的适体。
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摘要
An aptamer contains at least two parallel or antiparallel heteropolymeric nucleobase-containing sequences bonded together by Watson-Crick complementary base interaction or by homologous base interaction, provided that: (a) when the aptamer is single-stranded, the at least two sequences are bonded together by homologous base interaction; and (b) when the aptamer is a duplex and the at least two sequences are antiparallel to each other, the at least two sequences are bonded together by homologous base interaction. The aptamer can be used to bind ligands or to catalyze reactions when functioning as an aptazyme.
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