Indol derivatives as Adriano receptor analgesics

摘要

It refers to a derivative I in the formula, where n is 1-4; R1 and R2 are h or C1-C4 tar; R3 is h or C1-C6 tar, which can be replaced by hydrogen Xi; R4, R5, R6, R7 and R8 are h, hydroxi, C1-C6 tar, alcox C1-C6, benciloxi, etc. ]), amine (1 (1]]]]]]] - (1 - (n - (1 -) (1 - (1 -) (1 - (1) fluorine - (1 -) (1 - (1-amida, N - (2)) 6-dimethoxybenzene-5 - [(2R) - 2 - ((2R) - 2-hydroxy-2 - [4-hydroxy-3 - (hydroxy) phenyl] ethyl} amino] - 1-indo-2-carbohydramine;5 - [(2R) - 2 - (- (2R) - 2-hydroxy-2 - [4-hydroxy-3 - (hydroxymethyl) phenyl], (amino) propil] - N - (3-methylbencil) - 1h-indol-2-carboxamida, etc. It also mentions the preparation of a program and the synthesis of a drug containing it. These compounds are agonists for the B-2 adrenergic receptor and can be used in the treatment of diseases, inflammation, allergies or respiratory diseases.