A water soluble active polymer, which is hydrolytically stable is selected from the group consisting of poly(alkylene oxides), poly(oxyethylene polyols) and poly(olephine alcohols) with at least one active sulfone moiety. Activated poly(ethylene glycol) derivative having the structure R-(OCH2CH2)n-Y, wherein n equals 5 to 3 000, Y is the group selected from the group consisting of -SO2-CH=CH2 and -SO2-CH2-CH2-X, wherein X is halogen and their derivatives, whereby R means the same or other group like Y. A hydrolytically stable, biologically active conjugate, biosubstance, which comprises surface and at least one water soluble polymer derivative attached to that surface, the method for preparing poly(ethylene glycol) vinyl sulfone, the method of synthesis water soluble organic polymer with active sulfone group, the method for preparing conjugate substance and water soluble active polymer and the method for preparing conjugate of biologically active molecules and active derivative of poly(ethylene glycol).
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