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process for preparation of indole and azaindole cycloalcano acids and their pyrimido (1,2-a) indole carboxylic acid from the point of view of enantiomere pure and active derivatives thereof
process for preparation of indole and azaindole cycloalcano acids and their pyrimido (1,2-a) indole carboxylic acid from the point of view of enantiomere pure and active derivatives thereof
The invention relates to a method, an intermediate and an active derivative thereof for preparing naphthenic indole carboxylic acid, azaindole carboxylic acid and pyrimidinyl ((1,2-a) acid purified from a symmetrical angle. Toluene acetic acid is characterized by first esterification with chiral alcohols and then selective substitution of diarrhea in fatty carbon atoms.The product is halogenated in toluene group, and then reacts with suitable indole of naphthenic indole, naphthenic nitrogen indole or pyrimidine (1,2-a). This method is more accurate and pure to prepare symmetrical pure carboxylic acids, which are intermediates of high-value drugs.
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