首页> 外国专利> process for preparation of indole and azaindole cycloalcano acids and their pyrimido (1,2-a) indole carboxylic acid from the point of view of enantiomere pure and active derivatives thereof

process for preparation of indole and azaindole cycloalcano acids and their pyrimido (1,2-a) indole carboxylic acid from the point of view of enantiomere pure and active derivatives thereof

机译:从对映体纯的和活性的衍生物的观点看,吲哚和氮杂吲哚环烷酸及其嘧啶基(1,2-a)吲哚羧酸的制备方法

摘要

The invention relates to a method, an intermediate and an active derivative thereof for preparing naphthenic indole carboxylic acid, azaindole carboxylic acid and pyrimidinyl ((1,2-a) acid purified from a symmetrical angle. Toluene acetic acid is characterized by first esterification with chiral alcohols and then selective substitution of diarrhea in fatty carbon atoms.The product is halogenated in toluene group, and then reacts with suitable indole of naphthenic indole, naphthenic nitrogen indole or pyrimidine (1,2-a). This method is more accurate and pure to prepare symmetrical pure carboxylic acids, which are intermediates of high-value drugs.
机译:本发明涉及一种从对称角度纯化的环烷吲哚羧酸,氮杂吲哚羧酸和嘧啶基((1,2-a)酸)的制备方法,中间体及其活性衍生物。该产物在甲苯基中被卤化,然后与合适的环烷吲哚,环烷氮吲哚或嘧啶(1,2-a)反应,此方法更准确,更准确。制备对称的纯羧酸,它们是高价值药物的中间体。

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