3- (3-CHLORO-4-HYDROXYPHENYLAMINE) -4- (2-NITROPHENYL) -1H-PIRROL-2,5-DIONA AS A GLUCOGEN INHIBITOR CINASA-3 (GSK-3) SYNTHEASE.

摘要

3- (3-Chloro-4-hydroxyphenylamino) -4- (2-nitrophenyl) -1H-pyrrole-2,5-dione or a pharmaceutically acceptable salt or solvate thereof. The present invention provides the compound 3- (3-chloro-4-hydroxyphenylamino) -4- (2-nitrophenyl) -1H-pyrrol-2, 5- dione or a pharmaceutically acceptable salt or solvate thereof, as well as pharmaceutical compositions comprising this compound, as well as its use for the preparation of a medicament for the treatment of diseases associated with a need for inhibition of glycogen synthase kinase-3 (GSK-3), as for example in diabetes, in particular the Type 2 diabetes, dementia, Alzheimer's disease, manic depression or cancer. Accordingly, the compound is useful for the treatment and / or prophylaxis of mood disorders, such as schizophrenia, in a mammal, such as man, whose method comprises the administration of a pharmaceutically acceptable amount of a GSK inhibitor. -3. The compound is also useful for the treatment of neurotraumatic diseases in a mammal, such as man. The invention also provides the use of a GSK-3 inhibitor for the preparation of a medicament for the treatment and / or prophylaxis of mood disorders, schizophrenia, neurotraumatic diseases, cancer or hair loss. A suitable GSK-3 inhibitor is a compound according to claim 1 or a pharmaceutically acceptable derivative thereof.