IMPROVEMENTS IN OR RELATING TO COMPOUNDS FOR USE IN THE TREATMENT OF AIDS AND OTHER VIRAL DISEASES AND HIV-RELATED INFECTIONS AND COMPOSITIONS CONTAINING SUCH COMPOUNDS, METHODS OF TREATING SUCH DISEASES AND INFECTIONS AND METHODS OF MAKING SUCH COMPOUNDS AND COMPOSITIONS

摘要

The present invention provides methods for treating Acquired ImmunodeficiencySyndrome (AIDS) and other viral diseases and Human Immunodeficiency Virus(HIV) related infections by administering one or more compounds of formula I:wherein: the dotted line represents a single or a double bond; and R1 and R2are the same or different and independently of each other represent - CH2OH, -CH2OR4, -CH(OH)CH3, -CH(OR4)CH3 or a group represented by the formula: orsalts or hydrates thereof in a carrier which minimizes micellar formation orvan der Waals attraction of molecules of said compound. The invention alsoprovides S enantiomeric forms of such compounds which possess the ability toinhibit cell growth whilst being of low toxicity to such cells and methods ofmaking such compounds.