The present invention relates to a method for screening libraries of molecules showing specific interaction, such as binding activity or catalytic activity, with a target molecule. The method makes use of a primary library, which comprises the candidate molecules of the library marked with nucleic acid tags and a secondary library, which is used for amplifying and identifying the nucleic acid tags of the molecules in the primary library. The method may e.g. be used for the identification of new pharmaceuticals in which case the target molecule could be a receptor molecule.
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