CHIMERIC RECEPTORS WITH DISRUPTED DILEUCINE MOTIFS

摘要

A simple disruption of a dileucine motif in chimeric cell membrane receptors is taught. The disruption increases the capacity of the modified receptor to accumulate on the cell membrane relative to the unmodified receptor. The invention is particularly well suited for chimeric receptors comprising a portion of the CD28 protein that contains a dileucine motif.