首页> 外国专利> METHOD FOR DETERMINING THE IMPACT OF A MULTICOMPONENT SYNTHETIC PRODUCT MIXTURE ON THE BIOLOGICAL PROFILE OF A DISEASE WITHIN A GROUP OF LIVING SYSTEMS AND THE DEVELOPMENT OF NEW COMBINATORIAL INTERVENTIONS

METHOD FOR DETERMINING THE IMPACT OF A MULTICOMPONENT SYNTHETIC PRODUCT MIXTURE ON THE BIOLOGICAL PROFILE OF A DISEASE WITHIN A GROUP OF LIVING SYSTEMS AND THE DEVELOPMENT OF NEW COMBINATORIAL INTERVENTIONS

机译:确定一组生命系统中多组分合成产物混合物对疾病生物学特征影响的方法和新的联合干预措施

摘要

The invention provides a method for determining the impact of a chemical multicomponent mixture on the biological profile of a disease comprising the steps of: (a) determining a biological profile of the disease by comparing the biological profile of a group of living systems with symptoms of the disease with the biological profile of a reference (or healthy) group of living systems, using a multivariate analysis; (b) determining the impact of a series of samples of one or more synthetic compositions on the biological profile of the disease, in which samples the concentrations of the one or more synthetic compositions differ, using a multivariate analysis; (c) preparing a set of multicomponent synthetic product mixtures which are expected to display a desired impact on the biological profile of the disease on the basis of the information obtained in step (b); and (d) determining the impact of the set of multicomponent mixtures as prepared in step (c) on the biological profile of the disease using multivariate analysis. The invention also provides a method for preparing a medicament, and the use of a multicomponent synthetic product mixture as prepared in step (c) for preparing a synthetic product-based medicament.
机译:本发明提供了一种确定化学多组分混合物对疾病的生物学特性的影响的方法,该方法包括以下步骤:(a)通过将一组生命系统的生物学特性与以下症状进行比较来确定疾病的生物学特性:使用多变量分析,以参考(或健康)生命系统组的生物学特征分析疾病; (b)使用多变量分析确定一系列一种或多种合成组合物样品对疾病生物学特征的影响,其中一种或多种合成组合物的浓度不同。 (c)根据步骤(b)中获得的信息,制备一组预期对疾病的生物学特性显示出期望影响的多组分合成产物混合物; (d)使用多变量分析确定步骤(c)中制备的多组分混合物对疾病的生物学特性的影响。本发明还提供了一种制备药物的方法,以及在步骤(c)中制备的多组分合成产物混合物在制备基于合成产物的药物中的用途。

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