USE OF ULTRAVIOLET, NEAR-ULTRAVIOLET AND NEAR INFRARED RESONANCE RAMAN SPECTROSCOPY AND FLUORESCENCE SPECTROSCOPY FOR TISSUE INTERROGATION OF SHOCK STATES, CRITICAL ILLNESSES, AND OTHER DISEASE STATES

摘要

In an emergency medicine patient, accurate measurement of change or lack thereof from non-shock, non-ischemic, non-inflammation, non-tissue injury, non-immune dysfunction conditions is important and is provided, as practical, real-time approaches for accurately characterizing a patient's condition, using Raman (3) and/or fluorescence (30) spectroscopy with a high degree of accuracy. Measurement times are on the order of seconds. High-accuracy measurement is achieved with Raman spectroscopy interrogation of tissue. Simultaneous interrogation by NADH fluorescence spectroscopy may be used. Measurements may be non-invasive to minimally invasive. Preclinical (ultra-early) states of shock can be detected (5), severity can be determined, and the effectiveness of various treatments can be determined.