首页>
外国专利>
POTENT ONCOLYTIC HERPES SIMPLEX VIRUS FOR CANCER THERAPY
POTENT ONCOLYTIC HERPES SIMPLEX VIRUS FOR CANCER THERAPY
展开▼
机译:强大的溶息性单纯疱疹病毒用于癌症治疗
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention is directed to an oncolytic Herpes Simplex Virus having multiple cell membrane fusion mechanisms and preferably comprising a strict late viral promoter for effective conditional replication, such as in a malignant cell. In specific embodiments, the cell membrane fusion mechanisms are either from a mutant virus generated through random mutagenesis or through insertion of a fusogenic membrane glycoprotein, and in further specific embodiments the strict late viral promoter UL38p regulates expression of the glycoprotein.
展开▼