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AN INHIBITOR OF THE SHH SIGNALLING PATHWAY AND A TESTOSTERONE SUPRESSING AGENT FOR THE TREATMENT OF CANCER
AN INHIBITOR OF THE SHH SIGNALLING PATHWAY AND A TESTOSTERONE SUPRESSING AGENT FOR THE TREATMENT OF CANCER
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机译:SHH信号通路的抑制剂和睾丸激素抑制剂治疗癌症
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摘要
A method of protecting a patient from possible adverse effects of a treatment involving inhibition of the SHH-signalling pathway in the patient, the method comprising suppressing testosterone or its effect in the patient. A method of treating a proliferative disease such as cancer in a patient the method comprising inhibiting the SHH-signalling pathway and suppressing testosterone or its effect in the patient. Typically, the SHH-signalling pathway is inhibited using cyclopamine or a derivative thereof, and testosterone is suppressed using any one or more of a GnRH antagonist, a GnRH agonist, an androgen antagonist or a Sa-reductase inhibitor.
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