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Pyridyl- and pyrimidyl-piperazines for the treatment of substance abuse diseases
Pyridyl- and pyrimidyl-piperazines for the treatment of substance abuse diseases
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机译:吡啶基和嘧啶基哌嗪类药物治疗药物滥用疾病
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摘要
PURPOSE: Compounds of formula(1) represent a novel class of psychotropic agents by having high affinity for both 5-HT1A and 5-HT2 receptors and low to moderate 5-HT re-uptake inhibiting properties. CONSTITUTION: Formula(1); wherein R1 represents either halogen or hydrogen, R2 represents halogen, X is CH2, O, or S, R3 and R4 are the same or different and selected from hydrogen or lower alkyl, n is 2 or 3, and A is selected from the pyrimidyl- or pyridyl- groups; is useful for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addition to a drug or substance of abuse or for treatment thereof.
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