Cutting grooves subject innovation is a groove formed in the saw tooth thread is provided with a tie head portion (1) on both sides, and the fastening holes (2) formed in the tie head of the center on one side, the tie head lower side inward from both side surfaces ( 3), the two cutting grooves (3) and cutting holes (8) and, wherein the tie head (1) to the body 5 of the pipe-like cylindrical, linked by a connecting portion (4) formed between said body and the flat body part (6) forming a flat form to a side of the central portion 5, to a configured Sepharose tie, including a threaded portion 7 formed at the lower portion of the body (5).
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