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High-purity (fluoroalkyl)benzene derivative and process for producing the same

机译:高纯度(氟代烷基)苯衍生物及其制备方法

摘要

The process for producing a (fluoroalkyl)benzene derivative according to the present invention comprises a step of reducing the total content of group 3 to group 12 transition metals in an alkylbenzene derivative to 500 ppm or less in terms of metal atoms; a step of halogenating the branched alkyl group of the purified alkylbenzene derivative by a photohalogenation to obtain a (haloalkyl)benzene derivative; and a step of subjecting the (haloalkyl)benzene derivative to a halogen-fluorine exchange using HF in an amount of 10 mol or higher per one mole of the (haloalkyl)benzene derivative. The (fluoroalkyl)benzene derivative produced by the process is reduced in the content of impurities such as residual halogens and residual metals, and is useful as intermediates for functional chemical products for use in applications such as medicines and electronic materials.
机译:本发明的(氟代烷基)苯衍生物的制造方法包括以下步骤:将烷基苯衍生物中的第3族至第12族过渡金属的总含量降低至金属原子为500ppm以下。通过光卤化将纯化的烷基苯衍生物的支链烷基卤化以获得(卤烷基)苯衍生物的步骤;每1摩尔(卤代烷基)苯衍生物使用10摩尔以上的HF使(卤代烷基)苯衍生物进行卤素-氟交换的步骤。通过该方法生产的(氟烷基)苯衍生物减少了诸如残留卤素和残留金属之类的杂质的含量,并且可用作用于诸如药物和电子材料之类的功能性化学产品的中间体。

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