Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine

摘要

Methods are provided for facilitating psychological extinction of a deleterious, high-anxiety response that is disproportionate to the threat offered by a given stimulus. An afflicted subject is treated with a sub-antimicrobial dose of D-cycloserine in conjunction with extinction training. The methods are relevant for treatment of anxiety disorders, including phobic disorders and PTSD, in addition to other afflictions such as insomnia and erectile dysfunction.