Pharmaceutical composition containing at least one Compound with activity of CB1 receptor, or a prodrug, tautomero or Salt thereof as active Component suitable for the prophylaxis and / or treatment of diseases related to the CB1 receptor in patients for Treatment and / or Youth

摘要

For example, a new drug using 4.5-dihydro-1h-pirazol, combined with a lipasa inhibitor, is resistant to people receiving CB1 marijuana. These compounds and lipid inhibitors are particularly suitable for drug manufacturePeppermint for the treatment and / or prevention of obesity in adolescents and / or the treatment and / or prevention of drug-induced obesity in adolescents and adolescents. The favorite lipid inhibitor is Ortizpancyclines, ATL-962 and / or lipstatin. Compounds, combination and kit. Claim 2: Use according to claim 1 of a CB1 receptor antagonist compound of formula (1) or a prodrug, tautomer or salt thereof in combination with a lipase inhibitor compound in the manufacture of a medicament for treatment and 7th prophylaxis of obesity in adolescent and / or juvenile patients and / or for the treatment or prophylaxis of drug-induced obesity in adolescent patients: (as shown in formula (1) where R and R1 can be the same or different from each other and represent phenyl, thienyl or pyridyl unsubstituted or with 1, 2 or 3 Y substituents,C1-3 tar or Alcoy, hydroxi, halogen, trifluomethoxi, trifluoromethy, trifluoroxi, nitro, amino, mono-o dialquil (C1-2) - amine, mono-o dialquil (C1-2) - amido (c1-3) tar sulfur, dimethylamido (c1-3) alcoxi carbon, carboxyl, Sulfur trifluoride sulfur, cyanogen, amino acid, carbamate, sulfur and acetyl, or R and / or R1 for nafilo, R2 for H, hidrxi, c1-3 alcoxi, acetylene or acrylonitrile, and AA for one (I),Page: 1(III)(Iv) o (v)R4 and R5 represent h or c1-8 derivatives or non derivatives, respectively, or C3-8 cyclopropyl or R4 represents acetyl or dimethylamine, or 2,2,2-trifluoroethane or phenyl or pyridine, provided R5 represents h; R6 represents h or c1-3 without derivatives, BB represents sulfur or carbide, and R3 represents benzene, Phenyl, Tianjin or pyridine are not substituted, or there may be 1, 2 or 3 substitutes, and they may be the same or different,O R3 refers to c1-8 dendrite or non dendrite asphalt, or C3-8 cyclododecane or R3 refers to nafilo. 13. Claim 3: use a formula compound (1) according to the requirements of item 2, which is characterized by R as 4-chlorophenyl, R1 as phenyl, R2 as h, AA as R4 as h, R5 as methyl, BB as sulfur, R3 as 4-chlorophenyl and its salts.