Method of production of a conjugated capsular polissacaru00ecdeo and protein results in a covalent compound polissacaru00ecdeo - proteu00ecna for use as vaccine antu00ecgeno

摘要

Method of production of a conjugated capsular polissacaru00ecdeo and proteu00ecna that results in a covalent compound polissacaru00ecdeo - proteu00ecna for use as vaccine antu00ecgeno ".Which comprises four chemical reactions: (a) the partial hydrolysis of CSF for obtaining polymers of molecular weight less; (b) the oxidation of vicinal hydroxyl of the CSP in order to obtain a group aldeu00edThe reaction of the aldehyde group; (c) obtained in 'B' with the maleic acid, adipic acid (DHA); (d) reduction of the double bond obtained in 'C'; (E) reaction of the complex obtained in 'd' with the carboxyl of the protein.And the compound obtained is the vaccine antigen against encapsulated bacteria pathogens.