compound, pharmaceutical composition, and methods for modulating chemokine receptor activity in a mammal for treating, ameliorating, controlling or reducing the risk of an inflammatory and immunoregulatory disorder or disease, and rheumatoid arthritis

摘要

"COMPOSITION, PHARMACEUTICAL COMPOSITION, AND METHODS FOR MODULATING CHEMYCIN RECEIVER ACTIVITY IN A MAMMER FOR THE TREATMENT, IMPROVEMENT, CONTROL OR REDUCTION OF RISK OF INFLAMMATORY AND IMMEDIATE IRUMATORY DISEASE AND DISEASE Cyclopentyl compounds attached to a benzoxazinyl group through a starch moiety using benzoxazine ring nitrogen and further substituted with a heterocyclic moiety, these compounds represented by formula (I), which are used to modulate the CCR-2 chemokine receptor to prevent or treating inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune conditions such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.