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Compositions for the transport of therapeutic molecules into the lungs and use thereof for the treatment of lung cancers and pulmonary diseases
Compositions for the transport of therapeutic molecules into the lungs and use thereof for the treatment of lung cancers and pulmonary diseases
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机译:用于将治疗性分子转运到肺中的组合物及其在治疗肺癌和肺部疾病中的用途
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摘要
New compounds (I) comprise at least one therapeutic agent (II) for the treatment of lung cancer or pulmonary diseases and at least one carrier peptide (III) for increasing the bioavailability of (II) in the lungs, (III) being one of two specific peptides designated SynB4 and SynB6. New compounds (I) comprise at least one therapeutic agent (II) for the treatment of lung cancer or pulmonary diseases and at least one carrier peptide (III) for increasing the bioavailability of (II) in the lungs, (III) having the sequence Ala-Trp-Ser-Phe-Arg-Val-Ser-Tyr-Arg-Gly-Ile-Ser-Tyr-Arg-Arg-Ser-Arg (SynB4) or Arg-Gly-Gly-Arg-Leu-Ser-Tyr-Ser-Cit-Cit-Cit-Phe-Ser-Thr-Ser-Thr-Gly-Arg (SynB6). An Independent claim is also included for the use of the peptides (III) in the preparation of (I).
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