Use of multi-layered medicament formulation for the production of medicament released in colon

摘要

Use of a multi-layered medicament formulation essentially made up of a) a core containing a pharmaceutical active substance, b) an inner coating comprising a copolymer or mixture of copolymers, which are composed of 85 to 98 % of radically polymerised C1- to C4-alkyl esters of acrylic or methacrylic acid and 15 to 2 wt. % of (meth)acrylate monomer with quaternary ammonium group in the lakyl radical and c) an outer coating comprising a copolymer, which is composed of 75 to 95 wt. % of radically polymerised C1- to C4-alkyl esters of acrylic or methacrylic acid and 5 to 25 wt. % of (meth)acrylate monomer with an anionic group in the alkyl radical, for the production of the medicament.