METHOD FOR PREACHING THE RESPONSE TO THERAPY DIRECTED TO HER2.

摘要

Method for identifying a mammalian tumor that responds to a therapy directed to HER2, in which the mammalian tumor overexpresses HER2, the method comprising the step of analyzing a sample obtained from the mammalian tumor to detect an expression pattern, phosphorylation , or expression and phosphorylation, of one or a plurality of polypeptides consisting of: (a) IGFR polypeptide; (b) EGFR polypeptide; (c) NDF polypeptide; (d) phosphorylated S6 ribosomal polypeptide; (e) phosphorylated AKT polypeptide; and (f) phosphorylated ERK polypeptide; wherein the detected pattern of expression, phosphorylation, or expression and phosphorylation, identifies mammalian tumors.