Cloning and expression of binding proteins haemophilus somnus transferrin.

摘要

Vaccine composition consisting essentially of an adjuvant and a pharmaceutically acceptable carrier, and a binding protein transferrin H. somnus isolated immunogenic selected from the group consisting of (a) a binding protein 1 H. somnus transferrin having at least about 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 1-971, inclusive, of figure 3, (b) a binding protein 1 H. somnus transferrin having at least about 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 29-971 of, inclusive, of figure 3, (c) a binding protein 2 H. somnus transferrin having at least about 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 1-662, inclusive, of figure 4, and (d) a protein binding two tra nsferrina H. somnus having at least about 90% sequence identity to the contiguous sequence of amino acids shown at amino acid positions 20-662 of, inclusive, of Figure 4.