INTRATHYMIC ADMINISTRATION OF VIRAL VECTORS FOR THE INDUCTION OF IMMUNE TOLERANCE, THE PREVENTION OR TREATMENT OF IMMUNODEFICIENCIES OR AUTOIMMUNE DISEASES

摘要

The invention relates to the use of viral vectors able to stably integrateinto the genome of thymic stromal cells, or of intrathymic lymphocytes orlymphocytes precursors, for the manufacture of a medicine intended forintrathymic administration in the frame of the prevention or treatment ofgenetic immunodeficiencies, acquired immunodeficiencies, or for the inductionof immune tolerance of the organism to self or non-self gene products, cellsor tissues, or for the prevention or treatment of autoimmune diseases.