USE OF BOMBESIN/GASTRIN-RELEASING PEPTIDE ANTAGONIST FOR THE TREATMENT OF SEPSIS, ACUTE LUNG INJURY, SEPTIC SHOCK OR RHEUMATOID ARTHRITIS

摘要

The invention concerns the use of a bombesin/gastrin releasing peptideantagonist in the preparation of a pharmaceutical composition for thetreatment of inflammatory and immune-mediated inflammatory conditions, inparticular sepsis, acute lung injury and rheumatoid arthritis as well as forthe treatment or prophylaxis of brain disorders, pref~erably bipolar disorder,and in particular the different forms and/or subforms of bipolar disorder,such as mania, acute mania, severe mania, hypomania, depression, moder~atedepression, dysthymia, severe depression, episodes of mania and/or depression,psychosis/psychotic symptoms (e.g. hallucinations, delusions), mixed bipolarstate, bipolar I disorder, bipolar II disorder and/or rapid-cycling bipolardisorder. In particular, specific nonapeptides with antagonist propertiesagainst bombesin or bombesin-like peptides, such as the gastrin releasingpeptide, may be used in the treatment of in~flammatory and immune-mediatedinflammatory conditions as well as brain disorders.