ESTIMATION OF ACTIVITY OR INHIBITION OF PROCESSES INVOLVED IN NUCLEIC ACID MODIFICATION USING CHEMILUMINESCENCE QUENCHING

摘要

A method for determining the activity of a substance capable of altering the structure of a nucleic acid molecule from a first to a second state which is based upon the use of labelled nucleic acid molecules and/or complementary oligonucleotides. The label is a chemiluminescent molecule and a corresponding quencher molecule whose optical properties are different depending upon whether the nucleic acid molecule exist in said first or second state.