Composition comprising acyclic triterpenoid compounds with acyl-CoA?cholesterol acyltransferase inhibitory activity
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机译:包含具有酰基辅酶A?胆固醇酰基转移酶抑制活性的无环三萜类化合物的组合物
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摘要
The present invention is an acyl-Koei: cholesterol transition relates to acyclic triterpenoid-based compound and pharmaceutical compositions containing them having an enzyme inhibitory activity, more specifically the following formula (1) of the acyclic (acyclic) triterpenoids 2,3,22,23- tetra-hydroxy compounds of -2,6,10,15,19,23- -6,10,14,18- hexamethyl tetra-Xhosa-tetraene (2,3,22,23 -tertrahydroxy-2,6,10,15,19,23-hexamethyl-6,10,14,18-tetracosatetraene) this acyl-Koei: the compound or a cholesterol by checking the transition should effectively inhibit the activity of the enzyme hyperlipidemia due to hypercholesterolemia containing a pharmaceutically acceptable salt thereof as an active ingredient, and various related to cardiovascular disease preventing and treating or a food composition for such arteriosclerosis. ; Acyl-Koei: cholesterol transferase, 2,3,22,23- tetra-hydroxy -2,6,10,15,19,23- hexamethyl tetra -6,10,14,18- Cosa tetraene, cardiovascular related diseases
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