PHOSPHORYLATED method for labeling peptides METHOD selective adsorption PHOSPHORYLATED peptide complex compound used in such a manner METHOD FOR PRODUCING complexes and starting compounds for preparing compounds COMPLEX

摘要

1. method u043cu0435u0447u0435u043du0438u00a0 u0444u043eu0441u0444u043eu0440u0438u043bu0438u0440u043eu0432u0430u043du043du043eu0433u043e u043fu0435u043fu0442u0438u0434u0430 integrated compound formula (i);where x u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a u043bu0438u043du043au0435u0440u043du0443u044e group, and y is a group u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 u043cu0435u0447u0435u043du0438u00a0.;2. way to 1, where the connection u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a compound containing biotin as a group u043cu0435u0447u0435u043du0438u00a0.;3. method of adsorption u0444u043eu0441u0444u043eu0440u0438u043bu0438u0440u043eu0432u0430u043du043du043eu0433u043e u043fu0435u043fu0442u0438u0434u0430 using an integrated u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 of formula (i);where x u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a u043bu0438u043du043au0435u0440u043du0443u044e group, and y is a group u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 u043cu0435u0447u0435u043du0438u00a0.;4. a way to 3, where the connection u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a compound containing biotin as a group u043cu0435u0447u0435u043du0438u00a0.;5. the compound of formula (i);where x u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a u043bu0438u043du043au0435u0440u043du0443u044e group, and y is a group u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 u043cu0435u0447u0435u043du0438u00a0.;6. integrated connection under clause 5, where a group of u043cu0435u0447u0435u043du0438u00a0 u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a biotin.;7. method u043fu043eu043bu0443u0447u0435u043du0438u00a0 u0441u043eu0435u0434u0438u043du0435u043du0438u00a0 (i), including the scheme 1.;scheme 1;where r1 and r2, each u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du0443u044e group u0434u043bu00a0 u043eu0431u0440u0430u0437u043eu0432u0430u043du0438u00a0 u043bu0438u043du043au0435u0440u043du043eu0439 group x and y u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a group of u043cu0435u0447u0435u043du0438u00a0.;8. compound of formula (ii);where r1 u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u0435u0442 a u0440u0435u0430u043au0446u0438u043eu043du043du043eu0441u043fu043eu0441u043eu0431u043du0443u044e group, except for the u0430u043cu0438u043du043eu043cu0435u0442u0438u043bu044cu043du043eu0439 group, u0433u0438u0434u0440u043eu043au0441u0438u043cu0435u0442u0438u043bu044cu043du043eu0439 group, u0430u043cu0438u043du043eu0433u0440u0443u043fu043fu044b and u043au0430u0440u0431u043eu043au0441u0438u043bu044cu043du043eu0439 group.