METHOD FOR DETERMINING INDIVIDUAL SENSITIVITY TO BETA-ADRENOCEPTOR BLOCKERS IN ARTERIAL HYPERTENSION CASES

摘要

FIELD: medicine.;SUBSTANCE: method involves determining diene conjugates, lipid hydroperoxides, malonic dialdehyde, cholesterol, beta-lipoproteins concentration and erythrocyte cell membrane adrenoreactivity level in blood serum. Modification coefficient is calculated for each characteristic under consideration from formula M=(Ai-Amin)/(Amax-Amin), where Ai is the value of one of blood characteristics, Amin and Amax are the laboratory value spread for healthy people and arterial hypertension patients. Then, metabolic coefficient MC is calculated having value of each laboratory value M in consideration from formula M=(M_DC+M_HPL+M_MDA+M_Ch+M_LP+M_arm)/6, where M_DC is the M for diene conjugates, M_HPL is the M for lipid hydroperoxides, M_MDA is the M for malonic dialdehyde, M_Ch is the M for cholesterol, M_LP is the M for beta-lipoproteins, M_arm is the M for erythrocyte cell membrane adrenoreactivity level. MC value being less than 8, favorable adrenoceptor blockers influence is to be diagnosed.;EFFECT: high accuracy of the method.;1 tbl