ISOCITRATE DEHYDROGENASE, ITS GENE AND METHOD FOR APPLYING THEM IN TREATING PATIENTS FOR ADIPOSITY, HYPERLIPIEMIA AND HEPATIC FAT INFILTRATION IN CARRYING OUT LIPID BUOSYNTHESIS

摘要

FIELD: medicine.;SUBSTANCE: method involves increasing receptor activity, that is activated with proliferating agent of peroxis, by introducing NADP⁺-dependent isocitrate dehydrogenase (IDPc), IDPc gene or NADPH, selecting antisense molecule inhibiting fat deposit or nitroglycerides and cholesterol production using IDPc gene, and treating metabolism disorder diseases like adiposity, hyperlipiemia or hepatic fat infiltration by introducing antisense molecule of IDPc gene or IDPc gene inhibitor like oxalomalic acid or methyl isocitric acid.;EFFECT: enhanced effectiveness of treatment; reduced NADP level in cells.;5 cl, 10 dwg