or their pharmaceutically acceptable salts, solvates or hydrates wherein n means a whole number from 0 to 2; A represents optionally substituted phenyl; B represents oxygen (O), sulfur (S) atom or -NR6 wherein R6 represents hydrogen atom or alkyl; Y represents -OR7 wherein R7 represents hydrogen atom, alkyl, optionally substituted phenyl, aralkyl wherein aryl fragment means optionally substituted phenyl, cycloalkyl or cycloalkylalkyl; Z represents -C(R101)2-, -R102C=CR102-, -CC-, -C(R103)2S-, -C(O)O- or -C(O)NR10- wherein each among R10, R101, R102 and R103 represents independently hydrogen atom or alkyl; R1 and R2 represent independently hydrogen atom or alkyl; R3 represents hydrogen atom or alkyl; R4 and R5 represent independently hydrogen atom, (C1-C8)-alkyl or arylalkyl wherein aryl fragment means optionally substituted phenyl. Also, invention describes methods for preparing retinoid compounds, a pharmaceutical composition based on thereof and a method for treatment and/or prophylaxis of respiratory ways obstructive disease, cancer or dermatological disturbance or disorder. Invention provides preparing new compounds possessing useful biological properties.;EFFECT: improved treatment method, valuable medicinal properties of compounds and composition.;28 cl, 10 tbl, 16 ex"/>
RETINOID COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF RESPIRATORY WAY OBSTRUCTIVE DISEASE, CANCER OR DERMATOLOGICAL DISTURBANCE OF DISORDER
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RETINOID COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF RESPIRATORY WAY OBSTRUCTIVE DISEASE, CANCER OR DERMATOLOGICAL DISTURBANCE OF DISORDER
RETINOID COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS), PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR TREATMENT OF RESPIRATORY WAY OBSTRUCTIVE DISEASE, CANCER OR DERMATOLOGICAL DISTURBANCE OF DISORDER
FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy.;SUBSTANCE: invention relates to new biologically active heterocyclic retinoid compounds. Invention describes retinoid compounds corresponding to the formula (I): or their pharmaceutically acceptable salts, solvates or hydrates wherein n means a whole number from 0 to 2; A represents optionally substituted phenyl; B represents oxygen (O), sulfur (S) atom or -NR6 wherein R6 represents hydrogen atom or alkyl; Y represents -OR7 wherein R7 represents hydrogen atom, alkyl, optionally substituted phenyl, aralkyl wherein aryl fragment means optionally substituted phenyl, cycloalkyl or cycloalkylalkyl; Z represents -C(R101)2-, -R102C=CR102-, -CC-, -C(R103)2S-, -C(O)O- or -C(O)NR10- wherein each among R10, R101, R102 and R103 represents independently hydrogen atom or alkyl; R1 and R2 represent independently hydrogen atom or alkyl; R3 represents hydrogen atom or alkyl; R4 and R5 represent independently hydrogen atom, (C1-C8)-alkyl or arylalkyl wherein aryl fragment means optionally substituted phenyl. Also, invention describes methods for preparing retinoid compounds, a pharmaceutical composition based on thereof and a method for treatment and/or prophylaxis of respiratory ways obstructive disease, cancer or dermatological disturbance or disorder. Invention provides preparing new compounds possessing useful biological properties.;EFFECT: improved treatment method, valuable medicinal properties of compounds and composition.;28 cl, 10 tbl, 16 ex
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机译：技术领域：本发明涉及新的具有生物活性的杂环类视黄醇化合物。本发明描述了对应于式（I）的类视黄醇化合物：<图像文件=“ 00000002.GIF” he =“ 47” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 75” />或其药学上可接受的盐，溶剂化物或水合物，其中 n 表示0到2的整数; A代表任选取代的苯基; B代表氧（O），硫（S）原子或-NR 6 ，其中R 6 代表氢原子或烷基; Y代表-OR 7 ，其中R 7 代表氢原子，烷基，任选取代的苯基，芳烷基，其中芳基片段表示任选取代的苯基，环烷基或环烷基烷基; Z代表-C（R 101 ） 2 -，-R 102 C = CR 102 -，-CC -，-C（R 103 ） 2 S-，-C（O）O-或-C（O）NR 10 - R 10 ，R 101 ，R 102 和R 103 分别独立地表示氢原子或烷基。 R 1 和R 2 分别代表氢原子或烷基; R 3 代表氢原子或烷基; R 4 和R 5 分别代表氢原子，（C 1 -C 8 ）-烷基或芳基烷基，其中芳基片段是指任选取代的苯基。此外，本发明描述了制备类视黄醇化合物的方法，基于其的药物组合物以及用于治疗和/或预防呼吸道阻塞性疾病，癌症或皮肤病学障碍或病症的方法。本发明提供了制备具有有用生物学特性的新化合物。效果：改进的治疗方法，该化合物的有价值的医学特性和组成。28 cl，10 tbl，16 ex
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