Use of a specific K252a derivative for the treatment of neurodegenerative diseases characterized by pathological hyperphosphorylation and aggregation of tau proteins in neurofibrillary tangles

摘要

The present invention relates to the use of a specific indolocarbazole compound of the general formula 1 or a pharmaceutically acceptable salt thereof for the preparation of a pharmaceutical composition for the prevention or treatment of a neurodegenerative and / or dementing disease caused by the molecular pathology of microtubule-associated dew such as Alzheimer's disease, frontal appendicitis, Pick's disease, Parkinson's disease with dementia, corticobasal degeneration, Argyrophilic Grains Disease or supranuclear Palsy. A method of treating or preventing such diseases is also described. In addition, a method for identifying effective inhibitors of neurofibrillary degeneration and two methods for determining a suitable dosage of an inhibitor of PHF-like tau hyperphosphorylation for the treatment of a disorder characterized by neurofibrillary degeneration are described.