首页>
外国专利>
Promotion of transdermal administration of hydrophilic drugs
Promotion of transdermal administration of hydrophilic drugs
展开▼
机译:促进亲水性药物的透皮给药
展开▼
页面导航
摘要
著录项
相似文献
摘要
Methods, formulations, and drug delivery systems are provided for enhancing the flux of a transdermally administered hydrophilic drug using a basic permeation enhancer composition. The enhancer composition contains an inorganic hydroxide and a weaker, nitrogenous base, wherein the bases are selected such that a 0.1M aqueous solution of the nitrogenous base has a pH that is about 1.0 to about 6.5 lower than the pH of a 0.1M aqueous solution of the inorganic hydroxide. Additionally, the molar ratio of the nitrogenous base to the inorganic hydroxide in the enhancer composition is in the range of about 0.5n:1 to about 20n:1, `where n is the number of hydroxide ions per molecule of the inorganic hydroxide.
展开▼