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Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
Hansenula polymorpha yapsin deficient mutant strain and process for the preparation of recombinant proteins using the same
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机译:多形汉逊酵母 Yapsin缺陷型突变菌株及其制备重组蛋白的方法
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摘要
The present invention relates to a nucleic acid molecule comprising the HpYPS1 gene encoding H. polymorpha yapsin1, a polypeptide encoded by the nucleic acid molecule, a H. polymorpha mutant strain having reduced yapsin activity by mutation of the HpYPS gene encoding H. polymorpha yapsin1, a recombinant H. polymorpha strain expressing a foreign protein produced by introducing a gene encoding the foreign protein into the H. polymorpha mutant strain, and a process for preparing a foreign protein comprising culturing the recombinant H. polymorpha strain under conditions to express the foreign protein and isolating the foreign protein from the culture.
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