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Process for preparing 10α-4′-(S,S-dioxothiomorpholin-1′-yl)-10-deoxo-10-dihydroartemisinin

机译：制备10α-[4'-（S，S-二氧代硫吗啉-1'-基）]-10-脱氧-10-二氢青蒿素的方法

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摘要

A novel one-stage process for preparing 10α-[4′-(S,S-dioxothiomorpholin-1′-yl)]-10-deoxo-10-dihydroartemisinin (1a) by reacting a compound of the formula (1b); embedded image

in which X is a halogen atom with thiomorpholine dioxide at a temperature in the range of −30° C. to +20° C. is provided.

机译：一种新的一步法制备10α-[4'-（S，S-二氧代硫吗啉-1'-基）]-10-脱氧-10-二氢青蒿素（ 1 a ）通过使式（ 1 b ）的化合物反应; 在-30℃至+ 20℃的温度范围内，提供其中X是卤素原子和硫代吗啉二氧化物。 展开▼

著录项

公开/公告号US7241888B2

专利类型

公开/公告日2007-07-10

原文格式PDF

申请/专利权人 BETTINA HÖLZER;
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申请/专利号US20050145840

发明设计人 BETTINA HÖLZER;
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申请日2005-06-06

分类号C07D279/10;

国家 US

入库时间 2022-08-21 21:00:34

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3. Process for preparing 10alpha-4'-(S,S-dioxothiomorpholin-1'-yl)-10-deoxo-10-dihydroartemisinin [P] . 美国专利： US2005282804A1 . 2005-12-22

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