virion of a pneumovirus, method for producing pneumoviral virions, composition, use of a virion, and, method for the prevention or treatment of a pneumoviral infection

摘要

"VIRION OF A PNEUMOVIRUS, METHOD FOR PRODUCING PNEUMOVIRAL VIRIONS, COMPOSITION, USE OF A VIRION, AND METHOD FOR PREVENTION OR TREATMENT OF A PNEUMOVIRAL INFECTION". The present invention relates to pneumoviral virions comprising a viral genome that has a mutation in a gene coding for a protein that is essential for pneumovirus infectivity, so the mutation leads to a virus produced from only the viral genome missing infectivity, and thus the virion comprises the protein in a form and in an amount that is required for virion infectivity. The invention relates to methods for producing pneumoviral virions and for using virions to treat or prevent pneumoviral infection and disease. A preferred pneumoviral virion is a respiratory syncytial virus virion wherein preferably the gene for the G-binding protein is inactivated and complemented in trans.