Derivatives of N - (1H - indolil) - 1H indole - 3 - carboxamidas, its preparation and its application in Therapeutics

摘要

The invention relates to compounds of the general formula (I): (I) in which X1, X2, X3, X4, Z1, Z2, Z3, Z4 and Z5 independently represent one another of hydrogen or halogen atom or a C1-C6 alkyl group, C3-C7 cycloalkyl, C1-C6 fluoroalkyl, C1-C6 alkoxy, C1-C6 fluoroalkoxy, cyano, C (O) NR1R2, nitro, NR1R2, C1-C6 thioalkyl, -S (O) - C1-C6 alkyl, -S (O) 2- C1-C6 alkyl, SO2NR1R2, NR3COR4, NR3SO2R5, or aryl;X5 represents hydrogen or halogen atom or C1-C6 tar group, C1-C6 sulfur fluoride; R represents 4 -.Page: 16-O 7-selectively replaced Indian butene; represents hydrogen atom or C1-C6 tar group; n equals 0,1,2 or 3;R1 and R2, respectively, represent a hydrogen atom or C1-C6 tar, C3-C7 cyclopentadiene, C3-C7 cyclopentadiene-c1-c3 tar or arilo group;O R1 and R2 are combined and composed of a group of Azerbaijanis, pyridine, pyridine, azepine, morphine, sulfur, pyridine, pyridine and other nitrogen atoms. This group is replaced by a group of C1-C6, cyclopentyl compounds C3-C7, cyclopentyl glycol c3-c7-c1-c3-tar or arilo; R3 and R4 are representative, A hydrogen atom or a group of C1-C6 or arilo asphalts exist independently; R5 represents a group of C1-C6 or arilo asphalts; in an acid base or salt state, hydrate or solution state. 1. Treatment preparation and application.