Method for detecting a situation of excitoxicity or neuronal stress associated with a neurodegenerative disease comprising measuring in vitro the expression of phosphodiesterase 4

摘要

A method of detecting a situation of excitotoxicity or neuronal stress associated with a neurodegenerative disease in a subject, comprising measuring in vitro the expression of phosphodiesterase 4. Also disclosed is the use of an antisense nucleic acid or a compound from the pyrazolopyridine family for preparing a composition designed for the treatment of ALS.