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Controlled release oral dosage form comprising an erodable core containing a pharmaceutically active weak base
Controlled release oral dosage form comprising an erodable core containing a pharmaceutically active weak base
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机译:控释口服剂型,其包含含有药物活性弱碱的易蚀核心
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摘要
Disclosed herein is an oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; wherein the release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions. A process for preparing such a dosage form and the use of such a dosage form in medicine is also disclosed.
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