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manufacture of kromarografimatriser, a kromarografimatris, a vu00e4tskekromatografikolonn, prcess to isolate the target compounds and the use of a kromarografimatris for liquid chromatography
manufacture of kromarografimatriser, a kromarografimatris, a vu00e4tskekromatografikolonn, prcess to isolate the target compounds and the use of a kromarografimatris for liquid chromatography
The present invention relates to a method of manufacturing a chromatography matrix comprising providing a polysaccharide carrier comprising available hydroxyl groups; and reacting said hydroxyl groups with vinyl sulphonate to provide a sulphonate-functionalized (S-functionalized) cation exchanger. The hydroxyl groups of the carrier may be hydroxyls of the agarose polymer; or alternatively they may be provided on extenders such as polyhydroxyfunctional polymers. In one embodiment, the carrier is made of agarose with improved flow pressure properties.
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