HUMANIZED CHIMERIC ANTIBODIES AGAINST THE GANGLIOSID GD3

摘要

The present invention relates to a process for the production of humanized chimera antibody, wherein the chimera antibody is produced easily without changing any of the amino acids of its mouse antibody variable region. The invention also relates to humanized chimera antibodies obtainable by the claimed process and preferably being reactive with ganglioside, to transformants capable of producing humanized chimera antibodies, and to DNA molecules for use in the claimed process. Further objects of the invention are pharmaceutical compositions comprising humanized chimera antibodies, and the use of these antibodies for treating cancer.