13245 protein kinase myotonic dystrophy novel human and uses thereof.

摘要

An isolated molecule selected nucleic acid from the group consisting of: a) a nucleic acid molecule comprising a nucleotide sequence which is identical in at least 80% to the nucleotide sequence of SEQ ID NO: 1 or 3, the nucleic acid molecule encodes a polypeptide having kinase activity; b) a nucleic acid molecule comprising a fragment of at least 1400 contiguous nucleotides of the nucleotide sequence of SEQ ID NO: 1 or 3, wherein the nucleic acid molecule encodes a polypeptide having kinase activity; c) a nucleic acid molecule encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2; d) a nucleic acid molecule encoding a fragment of a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, wherein the fragment comprises at least 1000 contiguous amino acids of SEQ ID NO: 2 and has kinase activity; e) acid molecule nucleicoque encoding an allelic variant that naturally produces a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, wherein the molecule of nucleic acid hybridizes with a nucleic acid molecule comprising one of SEQ ID NO: 1, SEQ ID NO: 3 and a complement thereof, under stringent conditions, and wherein the nucleic acid molecule encodes a polypeptide having kinase activity.